However, it is still slightly polar because of the carboxyl group. The order of polarity from most polar to least polar is: Caffeine > Acetaminophen > Aspirin > ibuprofen. 12 Pentane 0.0 Paracetamol may interact with other APIs or excipients when used together, e.g., many drug formulations including paracetamol and caffeine irrespective of the fact that both active ingredients form a eutectic mixture (Bi et al., 2003). The one which can hydrogen bond will stick to the surface of the silica gel more firmly than the other one. I'm struggling to work out which ones are polar and which are non-polar, and why they adsorb and desorb the way they do. In TLC, caffeine has the lowest Rf value when the stationary phase is silica and CaSO4, and the mobile phase is Butyl Ethanoate and Trichloroethane. Determination Of Acetaminophen And Caffeine Using Reverse Phase Liquid… *Corresponding Author: * 1Dr.V. Lakshmi Narayanan 9 | Page Fig.7: Linearity solution (120% level) of paracetamol and caffeine Fig 8: Linearity solution (150% level) of paracetamol and caffeine 3.3 Precision The precision of the method expressed as the relative standard deviation not more than 1.0% of both Caffeine is water soluble, so it is a polar compound. The experiment D of sample ‘B’ clearly showed positive outcome and indicated the presence of paracetamol as violet colour was achieved. 3. Burdick & Jackson solvents are arranged in order of increasing polarity index, a relative measure of the degree of interaction of the solvent with various polar test solutes. Paracetamol is soluble in alcohols, but the solubility decreases with an increase in the length of the carbon chain in the n-alcohol homologous series (methanol to 1-octanol). Which is more polar; caffeine, aspirin or paracetamol? The atom with a higher electronegativity will have a slightly more negative charge due to the attraction of more electrons, causing an unequal sharing of electrons. Advise people to take into account dietary and other medicinal sources of caffeine if paracetamol with caffeine is being taken so that they do not consume more than the recommended maximum of 520 mg caffeine per day. Caffeine is a polar molecule due to the electronegativity difference between the carbon-oxygen single polar covalent bonds and carbon nitrogen single polar covalent bonds. It is most attracted to the stationary phase. Liver problems have happened with paracetamol. People were also often taking more than 1 drug that had paracetamol. Aspirin is less polar than caffeine and acetaminophen because of the ether, but it is more polar than ibuprofen. ... caffeine is more polar than paracetamol. Caffeine is present in a variety of foods and beverages as well as in herbal, prescription and over-the-counter medicines. The key to determining if something is polar or not is by determining if it is water soluble. The fixed combination of acetylsalicylic acid, paracetamol and caffeine is more effective than single substances and dual combination for the treatment of headache: a multicentre, randomized, double-blind, single-dose, placebo-controlled parallel group study Most of the time, problems happened in people taking more than 4,000 mg (milligrams) of paracetamol in a day. The solubility of paracetamol in water is much lower than in other polar solvents such as the alcohols. Discussion. Sometimes, this has led to liver transplant or death. This medicine has paracetamol (acetaminophen) in it. However, compound B is more polar and travel slowly in the mobile phase. 9. Ibuprofen is the least polar because of the large alkyl group coming off of the benzene ring.